04
2019
-
07
Chinese scientists create candidate vaccine for African swine fever
(Source: People's Daily)
The reporter learned from the briefing on scientific research progress of the Chinese Academy of Agricultural Sciences on the 24th that the African swine fever vaccine independently developed by the Harbin Veterinary Research Institute has achieved phased results. Laboratory research results show that it has good biosafety and immune protection effects.
According to Bu Zhigao, director of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, five major progresses have been made in the creation of the African swine fever vaccine: First, the isolation of the first African swine fever virus in my country. The virus cell isolation and culture system and animal infection model were established, and its biological characteristics such as infectivity, pathogenicity and transmission ability were systematically studied, and the genome characteristics and evolution of the epidemic strains of African swine fever in my country were revealed. relation. The second is to create candidate vaccines for African swine fever. Laboratory studies have proved that two of the candidate vaccine strains have good biosafety and immune protection effects. Third, the two candidate vaccine strains have strong in vitro and in vivo genetic stability. The two candidate vaccine strains were successively passaged in primary cells in vitro, and there was no significant change in their biological characteristics and genome sequences, and no obvious virulence reversion was found in pigs after successive passages in vivo. Fourth, the minimum protective inoculation dose is clarified to prove the safety of high-dose and repeated-dose inoculation. Fifth, the preclinical pilot product process research has been initially completed. At present, the production seed bank of two candidate vaccines has been established, the purity and exogenous virus inspection of vaccine production seed batches have been preliminarily completed, and the cell culture and freeze-drying processes of the candidate vaccines have been preliminarily optimized.
After the outbreak of African swine fever, the Central Committee of the Communist Party of China and the State Council attached great importance to scientific research on epidemic prevention and control. According to the unified deployment of the Party Group of the Ministry of Agriculture and Rural Affairs, the Chinese Academy of Agricultural Sciences took the prevention and control of African swine fever as a major scientific research task to serve the national strategic needs and gathered superior resources. , the first time to set up an African swine fever prevention and control scientific and technological project team, with Harbin Veterinary Research Institute, Lanzhou Veterinary Research Institute, Beijing Animal Husbandry and Veterinary Research Institute, Shanghai Veterinary Research Institute, Lanzhou Animal Husbandry and Veterinary Medicine Research Institute, Feed Institute, etc. as member units , Gathering elite forces to form a research team, and through the stable support of scientific and technological innovation projects, focusing on vaccine research and development, day and night, day and night, urgently carry out joint scientific and technological research on vaccines, immune mechanisms, diagnostic testing, disinfection and insecticide technology.
At present, the African Swine Fever Prevention and Control Science and Technology Project Team of the Chinese Academy of Agricultural Sciences has completed the whole genome determination of African swine fever virus in terms of immune mechanism, diagnostic testing, disinfection and insecticidal technology product development, cloned and expressed related genes, and constructed a model Innate immune and inflammatory response signaling pathways derived from animals and pigs, screened out a number of innate immunosuppressive viral genes, and completed the research on the immune suppression mechanism of some genes; developed viral nucleic acids with fast detection speed, high sensitivity and specificity, and good stability and antigens rapid detection kits; 12 tick species, including Ornithium lahore, Ixodes vulgaris, and D. prairie, were collected for artificial culture and life history observation, and new formulations of fast-disinfecting chemical drugs were screened out. The effective formula of botanical insecticide; the formula of compound quaternary ammonium salt disinfectant was screened out, and the pilot production research was completed.
It is reported that the Chinese Academy of Agricultural Sciences will accelerate the pilot and clinical trials, as well as various research work on vaccine production based on the research progress in the vaccine laboratory stage, and complete the immune mechanism, diagnostic testing, disinfection and insecticide technology as soon as possible. It provides timely, effective and powerful scientific and technological support for the needs of the country and the industry.
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